A patient with 10 – 29 days of opioid overlap from different prescribers in a six month period is more than 10 times more likely to die from opioid overdose death.

Higher daily doses of opioids are associated with increased risk of overdose death. A patient is three times more likely to die from an opioid overdose at 80-120 MME/d.

Opioid/sedative hypnotic overlap is associated with increased risk of overdose death, and the risk increases significantly with more days of overlap.